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KMID : 0984920170190010025
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Journal of Skin Barrier Research
2017 Volume.19 No. 1 p.25 ~ p.29
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Psoriasis and Skin Barrier
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Lee Si-Hyung
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Abstract
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Skin barrier is crucial for maintenance of healthy skin by preventing the loss of water as well as preventing entrance of pathogenic microorganisms or irritant. Since proliferation of keratinocytes is induced by disruption of skin barrier, impaired barrier function has been suggested to involve the development of proliferative skin disease, including psoriasis, which is well known disease expressing T helper 17 cell-related inflammation. Interestingly, skin barrier-related molecules, including filaggrin, loricrin and ceramide, are down-regulated in lesional skin of psoriasis. Moreover, water-holding capacity and barrier recovery are also impaired in psoriatic lesion. Mice expressing activated STAT3 at keratinocytes showed disrupted barrier function as well as psoriasis-like skin inflammation. Recent studies demonstrated that defects in various skin barrier-related genes, including late cornified envelop proteins, were associated with a risk of psoriasis. In conclusion, skin barrier impairment might have close relationship with psoriasis. However, further studies are required to determine whether impaired skin barrier plays causative role or not in the development of psoriasis.
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KEYWORD
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Proliferation, Psoriasis, Skin barrier
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